Detalles de la búsqueda
1.
Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3ß Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model.
Bioorg Chem
; 139: 106700, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37392559
2.
Transcriptome profiling reveals that VNPP433-3ß, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Mol Carcinog
; 61(7): 643-654, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35512605
3.
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Curr Opin Oncol
; 29(3): 210-220, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28282343
4.
Regulation of androgen receptor activity by tyrosine phosphorylation.
Cancer Cell
; 10(4): 309-19, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17045208
5.
Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation.
Biomed Pharmacother
; 177: 116934, 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38889639
6.
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Carcinogenesis
; 34(1): 199-210, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23042302
7.
Targeted Degradation of Androgen Receptor by VNPP433-3ß in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation.
Cancers (Basel)
; 15(4)2023 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36831540
8.
Murine toxicology and pharmacokinetics of lead next generation galeterone analog, VNPP433-3ß.
Steroids
; 192: 109184, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36702363
9.
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Front Oncol
; 13: 1240996, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37766871
10.
Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus.
Breast Cancer Res Treat
; 133(1): 137-44, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21842418
11.
Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice.
Eur J Med Chem
; 238: 114441, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35617854
12.
Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3ß.
Steroids
; 185: 109062, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35690119
13.
Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3ß: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.
Cells
; 11(17)2022 08 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36078112
14.
Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.
Drug Metab Dispos
; 38(4): 539-44, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20233842
15.
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.
Cancers (Basel)
; 12(11)2020 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33217941
16.
The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer.
Urol Oncol
; 27(1): 53-63, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19111799
17.
Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.
Mol Cancer Ther
; 7(1): 121-32, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18202015
18.
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.
Mol Cancer Ther
; 7(9): 2828-36, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18790763
19.
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.
Mol Cancer Ther
; 7(8): 2348-57, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18723482
20.
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.
Cancers (Basel)
; 11(3)2019 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30832411