Detalles de la búsqueda
1.
Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-l,l-2,6-diaminopimelic acid desuccinylase as potential antibiotics.
Bioorg Med Chem Lett
; 83: 129177, 2023 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36764468
2.
Atomic-Resolution 1.3 Å Crystal Structure, Inhibition by Sulfate, and Molecular Dynamics of the Bacterial Enzyme DapE.
Biochemistry
; 60(12): 908-917, 2021 03 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-33721990
3.
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
J Org Chem
; 86(4): 3377-3421, 2021 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33544599
4.
Peculiar substrate specificity of δ1-pyrroline-5-carboxylate reductase in the obligately fermentative bacterium Zymomonas mobilis.
Mol Biol Rep
; 48(8): 6205-6211, 2021 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-34331182
5.
The Legionella pneumophila effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.
J Biol Chem
; 293(9): 3307-3320, 2018 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29301934
6.
Structural Evidence of a Major Conformational Change Triggered by Substrate Binding in DapE Enzymes: Impact on the Catalytic Mechanism.
Biochemistry
; 57(5): 574-584, 2018 02 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29272107
7.
A family of metal-dependent phosphatases implicated in metabolite damage-control.
Nat Chem Biol
; 12(8): 621-7, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27322068
8.
Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters.
Environ Sci Technol
; 52(21): 12388-12401, 2018 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30284819
9.
The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism.
Nucleic Acids Res
; 44(2): 595-607, 2016 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26400178
10.
Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc Natl Acad Sci U S A
; 112(41): 12693-8, 2015 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26420866
11.
Biochemical and Structural Characterization of a Five-domain GH115 α-Glucuronidase from the Marine Bacterium Saccharophagus degradans 2-40T.
J Biol Chem
; 291(27): 14120-14133, 2016 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129264
12.
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.
Mol Syst Biol
; 12(12): 893, 2016 Dec 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27986836
13.
Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.
J Biol Chem
; 290(30): 18678-98, 2015 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26071590
14.
Biochemical and Structural Insights into Enzymatic Depolymerization of Polylactic Acid and Other Polyesters by Microbial Carboxylesterases.
Biomacromolecules
; 17(6): 2027-39, 2016 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27087107
15.
The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity.
Nucleic Acids Res
; 42(17): 11144-55, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25200083
16.
Gene selection and cloning approaches for co-expression and production of recombinant protein-protein complexes.
J Struct Funct Genomics
; 16(3-4): 113-28, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26671275
17.
Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity.
Biochemistry
; 54(28): 4342-53, 2015 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26115006
18.
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry
; 54(5): 1294-305, 2015 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25632825
19.
Inhibition of the dapE-Encoded N-Succinyl-L,L-diaminopimelic Acid Desuccinylase from Neisseria meningitidis by L-Captopril.
Biochemistry
; 54(31): 4834-44, 2015 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26186504
20.
Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.
J Biol Chem
; 288(12): 8101-8110, 2013 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23364794