Detalles de la búsqueda
1.
Discovery of ASP5878: Synthesis and structure-activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity.
Bioorg Med Chem
; 59: 116657, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35219181
2.
Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.
Bioorg Med Chem
; 33: 116019, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33486159
3.
Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg Med Chem
; 28(10): 115453, 2020 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32278710
4.
Intrinsic graph structure estimation using graph Laplacian.
Neural Comput
; 26(7): 1455-83, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24708372
5.
Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial.
Trials
; 25(1): 6, 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38166992
6.
Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543.
Bioorg Med Chem
; 21(13): 3934-48, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23651509
7.
Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor.
Endocr Res
; 38(3): 168-183, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23374077
8.
Intraplacental injection of AAV9-CMV-iCre results in the widespread transduction of multiple organs in double-reporter mouse embryos.
Exp Anim
; 72(4): 460-467, 2023 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37183025
9.
Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 20(10): 3263-79, 2012 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22507206
10.
Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice.
J Pharmacol Sci
; 120(1): 36-44, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22971845
11.
Slow slip source characterized by lithological and geometric heterogeneity.
Sci Adv
; 6(13): eaay3314, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-32232148
12.
Reproductive and developmental toxicity screening test of tetrahydrofurfuryl alcohol in rats.
Reprod Toxicol
; 25(2): 231-8, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18191536
13.
Higher susceptibility of newborn than young rats to 3-methylphenol.
J Toxicol Sci
; 28(2): 59-70, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12820538
14.
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Epilepsy Res
; 108(7): 1158-67, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24951328
15.
Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats.
J Pharm Pharmacol
; 66(7): 975-87, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24533859
16.
Unexpected biotic resilience on the Japanese seafloor caused by the 2011 Tohoku-Oki tsunami.
Sci Rep
; 4: 7517, 2014 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25515588
17.
Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice.
Eur J Pharmacol
; 715(1-3): 246-55, 2013 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23707905
18.
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.
Naunyn Schmiedebergs Arch Pharmacol
; 385(4): 423-36, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22139434
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