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1.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
2.
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Bioorg Med Chem Lett
; 25(7): 1448-52, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25690789
3.
Effect of LX4211 on glucose homeostasis and body composition in preclinical models.
J Pharmacol Exp Ther
; 350(2): 232-42, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24849925
4.
Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.
Bioorg Med Chem Lett
; 24(16): 3886-90, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25037917
5.
Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.
Xenobiotica
; 43(3): 253-62, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22928802
6.
Early toxicology signal generation in the mouse.
Toxicol Pathol
; 38(3): 452-71, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20305093
7.
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase.
Bioorg Med Chem Lett
; 19(23): 6780-3, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19836229
8.
Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6784-7, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19836232
9.
Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.
PLoS One
; 9(5): e98151, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24852423
10.
In vivo toxicology of excipients commonly employed in drug discovery in rats.
J Pharmacol Toxicol Methods
; 68(2): 284-295, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23499653
11.
Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).
J Med Chem
; 53(24): 8650-62, 2010 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21090716
12.
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
J Med Chem
; 52(20): 6201-4, 2009 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-19785435
13.
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
J Med Chem
; 52(13): 3941-53, 2009 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-19489538
14.
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
J Med Chem
; 51(13): 3684-7, 2008 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18557609
15.
A new paradigm for improving oral absorption of drugs in discovery: role of physicochemical properties, different excipients and the pharmaceutical scientist.
Future Med Chem
; 2(1): 1-5, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21426039
16.
Development and application of a high-throughput formulation screening strategy for oral administration in drug discovery.
Future Med Chem
; 2(9): 1391-8, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21426133
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