Detalles de la búsqueda
1.
Human pharmacokinetics of XBD173 and etifoxine distinguish their potential for pharmacodynamic effects mediated by translocator protein.
Br J Clin Pharmacol
; 88(9): 4230-4236, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35524344
2.
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.
Bioorg Med Chem Lett
; 25(24): 5792-6, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26531152
3.
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Bioorg Med Chem Lett
; 22(17): 5445-50, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22863202
4.
Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.
Bioorg Med Chem Lett
; 20(12): 3708-12, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20493697
5.
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
J Pharmacol Exp Ther
; 331(2): 470-84, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19704033
6.
A new pyridazine series of GABAA alpha5 ligands.
J Med Chem
; 48(19): 6004-11, 2005 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-16162003
7.
Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat.
J Psychopharmacol
; 19(2): 149-58, 2005 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15728436
8.
Automated sample preparation and LC-MS for high-throughput ADME quantification.
Curr Opin Drug Discov Devel
; 5(1): 52-8, 2002 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-11865673
9.
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
J Med Chem
; 47(24): 5829-32, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537339
10.
Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
J Med Chem
; 47(9): 2176-9, 2004 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15084116
11.
3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
J Med Chem
; 47(7): 1807-22, 2004 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-15027873
12.
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
J Med Chem
; 45(2): 492-503, 2002 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11784153
13.
2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.
Bioorg Med Chem Lett
; 17(9): 2643-8, 2007 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17314044
14.
High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry.
Anal Bioanal Chem
; 385(1): 114-21, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16604343
15.
Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.
Rapid Commun Mass Spectrom
; 20(5): 851-7, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16470510
16.
Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
Bioorg Med Chem Lett
; 16(4): 872-5, 2006 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16303300
17.
'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching.
Rapid Commun Mass Spectrom
; 19(18): 2597-602, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16106348
18.
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.
Rapid Commun Mass Spectrom
; 19(18): 2659-70, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16124034
19.
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
Bioorg Med Chem Lett
; 15(16): 3665-9, 2005 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15993598
20.
Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment.
Rapid Commun Mass Spectrom
; 16(11): 1065-71, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-11992509