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1.
A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.
Oncologist
; 26(10): e1844-e1853, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34132450
2.
Pharmacokinetics and ADME Characterization of Intravenous and Oral [14C]-Linerixibat in Healthy Male Volunteers.
Drug Metab Dispos
; 49(12): 1109-1117, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34625435
3.
Pharmacokinetics and Pharmacodynamics of the SGLT2 Inhibitor Remogliflozin Etabonate in Subjects with Mild and Moderate Renal Impairment.
Drug Metab Dispos
; 43(7): 1077-83, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25934577
4.
Regional gastrointestinal delivery of remogliflozin etabonate in humans.
Biopharm Drug Dispos
; 34(2): 79-86, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23111980
5.
Assessment of the drug interaction risk for remogliflozin etabonate, a sodium-dependent glucose cotransporter-2 inhibitor: evidence from in vitro, human mass balance, and ketoconazole interaction studies.
Drug Metab Dispos
; 40(11): 2090-101, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22851617
6.
First-in-Human Study for a Selective Rearranged During Transfection Tyrosine Kinase Inhibitor, GSK3352589, to Investigate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(4): 334-345, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33606922
7.
Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin.
BMC Pharmacol Toxicol
; 22(1): 34, 2021 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34120651
8.
First-in-Human Studies for a Selective RET Tyrosine Kinase Inhibitor, GSK3179106, to Investigate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 8(2): 234-245, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30277655
9.
Creatine ( methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA.
J Appl Physiol (1985)
; 124(1): 1-9, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28860169
10.
Geriatrics 2030: Developing Drugs to Care for Older Persons-A Neglected and Growing Population.
Clin Pharmacol Ther
; 107(1): 53-56, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31667834
11.
Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans.
J Appl Physiol (1985)
; 116(12): 1605-13, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24764133
12.
Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus.
BMC Pharmacol Toxicol
; 14: 25, 2013 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23631443
13.
First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus.
BMC Pharmacol Toxicol
; 14: 26, 2013 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23668634
14.
Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes.
Diabetes Care
; 35(11): 2198-200, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23011728
15.
Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus.
J Clin Pharmacol
; 50(6): 623-35, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20056803
16.
Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind study.
J Clin Pharmacol
; 50(6): 636-46, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20200268
17.
Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers.
Am J Physiol Gastrointest Liver Physiol
; 287(2): G363-9, 2004 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15246968
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