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1.
Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.
J Biol Chem
; 288(8): 5673-81, 2013 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23271737
2.
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.
Antimicrob Agents Chemother
; 57(7): 3358-68, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23650168
3.
N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.
Bioorg Med Chem Lett
; 23(16): 4663-8, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23809849
4.
Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.
Bioorg Med Chem Lett
; 23(15): 4447-52, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23773863
5.
Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.
Bioorg Med Chem Lett
; 23(14): 4267-71, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23735741
6.
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Bioorg Med Chem Lett
; 23(13): 3841-7, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23726345
7.
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.
ACS Med Chem Lett
; 14(2): 199-210, 2023 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36793435
8.
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
Bioorg Med Chem Lett
; 21(1): 398-404, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21087861
9.
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
J Med Chem
; 63(9): 4978-4996, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32369358
10.
Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
J Med Chem
; 63(17): 10061-10085, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787083
11.
Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.
J Med Chem
; 48(17): 5580-8, 2005 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-16107158
12.
Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution.
J Med Chem
; 57(5): 1770-6, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23506530
13.
Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.
J Med Chem
; 56(12): 5142-50, 2013 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23730910
14.
Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.
Bioorg Med Chem
; 15(7): 2690-700, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17306550
15.
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem Lett
; 17(12): 3362-6, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17451954
16.
Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex.
Bioorg Med Chem Lett
; 13(15): 2539-41, 2003 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12852961
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