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1.
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Bioorg Med Chem Lett
; 26(20): 5092-5097, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27658368
2.
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.
Bioorg Med Chem Lett
; 23(16): 4627-32, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23831134
3.
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
J Med Chem
; 65(19): 13052-13073, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36178776
4.
What We Learned in 25 Years of Interactive Molecular Design Sessions.
ChemMedChem
; 16(18): 2760-2763, 2021 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-34374230
5.
2-Phenoxy-nicotinamides are potent agonists at the bile acid receptor GPBAR1 (TGR5).
ChemMedChem
; 8(4): 569-76, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23225346
6.
Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand.
Angew Chem Int Ed Engl
; 44(28): 4400-4, 2005 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-15952226
7.
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
Angew Chem Int Ed Engl
; 42(22): 2507-11, 2003 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12800172
8.
A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values.
ChemMedChem
; 1(6): 611-21, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16892401
9.
Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket.
ChemMedChem
; 1(11): 1205-15, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17001711
10.
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.
Bioorg Med Chem
; 14(15): 5357-69, 2006 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16621574
11.
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.
Org Biomol Chem
; 4(12): 2364-75, 2006 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16763681
12.
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
Bioorg Med Chem Lett
; 15(23): 5344-52, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16213138
13.
Fluorine in medicinal chemistry.
Chembiochem
; 5(5): 637-43, 2004 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15122635
14.
Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.
Chembiochem
; 5(5): 666-75, 2004 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15122639
15.
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.
Org Biomol Chem
; 2(9): 1339-52, 2004 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15105924
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