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1.
A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers.
Eur J Clin Pharmacol
; 76(8): 1135-1141, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32472157
2.
Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans.
Xenobiotica
; 45(9): 757-65, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25869242
3.
In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats.
Xenobiotica
; 45(6): 488-94, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25539455
4.
Human mass balance, metabolite profile and identification of metabolic enzymes of [¹4C]ASP015K, a novel oral janus kinase inhibitor.
Xenobiotica
; 45(10): 887-902, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25986538
5.
Simultaneous determination of a novel oral Janus kinase inhibitor ASP015K and its sulfated metabolite in rat plasma using LC-MS/MS.
Biomed Chromatogr
; 29(7): 967-9, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25380383
6.
In vitro-in vivo extrapolations to evaluate the effect of concomitant drugs on tacrolimus (FK506) exposure.
Biopharm Drug Dispos
; 36(5): 265-74, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25600613
7.
Impact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole.
Xenobiotica
; 44(10): 926-32, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24666334
8.
Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506).
Biopharm Drug Dispos
; 35(9): 501-12, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25059890
9.
In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506).
Biopharm Drug Dispos
; 35(3): 135-44, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24822242
10.
Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier.
Biopharm Drug Dispos
; 33(6): 304-15, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22847220
11.
The Bioequivalence of Two Peficitinib Formulations, and the Effect of Food on the Pharmacokinetics of Peficitinib: Two-Way Crossover Studies of a Single Dose of 150 mg Peficitinib in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(3): 283-290, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32618438
12.
Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects.
Clin Drug Investig
; 40(5): 469-484, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-32274653
13.
Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects with Normal and Impaired Renal Function.
Clin Drug Investig
; 40(2): 149-159, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31729626
14.
Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function.
Clin Pharmacol Drug Dev
; 9(6): 699-708, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31833184
15.
YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model.
Int J Oncol
; 32(3): 545-55, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18292931
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