Detalles de la búsqueda
1.
Semi-mechanistic population pharmacokinetic/pharmacodynamic modeling of a Plasmodium elongation factor 2 inhibitor cabamiquine for prevention and cure of malaria.
Antimicrob Agents Chemother
; 67(12): e0089123, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37966273
2.
Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models.
Malar J
; 22(1): 199, 2023 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37381013
3.
An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2.
Toxicol Appl Pharmacol
; 443: 116006, 2022 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35367236
4.
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.
Malar J
; 21(1): 151, 2022 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35570264
5.
Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review.
BMC Infect Dis
; 21(1): 1274, 2021 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34930178
6.
Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32041711
7.
Designing the next generation of medicines for malaria control and eradication.
Malar J
; 12: 187, 2013 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-23742293
8.
Malaria Elimination in Africa: Rethinking Strategies for Plasmodium vivax and Lessons from Botswana.
Trop Med Infect Dis
; 8(8)2023 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37624330
9.
The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.
Front Cell Infect Microbiol
; 13: 1211613, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37457953
10.
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
Nat Commun
; 14(1): 5205, 2023 08 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37626093
11.
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.
Lancet Infect Dis
; 23(10): 1164-1174, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37414066
12.
Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.
Malar J
; 11: 45, 2012 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22333675
13.
Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis.
Front Immunol
; 12: 663041, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34113343
14.
Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
Lancet Infect Dis
; 21(12): 1713-1724, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34715032
15.
The Pan African Vivax and Ovale Network (PAVON): Refocusing on Plasmodium vivax, ovale and asymptomatic malaria in sub-Saharan Africa.
Parasitol Int
; 84: 102415, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34216801
16.
Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study.
Lancet Microbe
; 2(11): e617-e626, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34977830
17.
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
Antimicrob Agents Chemother
; 54(9): 3537-44, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20547801
18.
Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum.
Malar J
; 9: 339, 2010 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21108786
19.
Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection.
ACS Infect Dis
; 5(11): 1831-1842, 2019 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31479238
20.
Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
Nat Commun
; 14(1): 5447, 2023 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37673924