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1.
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene
; 26(5): 633-40, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16909123
2.
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer Res
; 59(19): 4919-26, 1999 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-10519405
3.
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Oncogene
; 19(48): 5525-33, 2000 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-11114730
4.
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Cell Death Differ
; 9(7): 702-9, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12058275
5.
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.
Leukemia
; 17(2): 451-7, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12592346
6.
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
J Med Chem
; 42(8): 1333-40, 1999 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-10212118
7.
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
J Biol Chem
; 276(19): 16161-7, 2001 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11154688
8.
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis
; 21(1): 113-6, 2000 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-10607742
9.
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochem Biophys Res Commun
; 252(1): 111-6, 1998 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-9813154
10.
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorg Med Chem Lett
; 11(6): 761-4, 2001 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-11277514
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