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1.
Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence.
BMC Genomics
; 22(1): 869, 2021 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34856941
2.
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Biochem Biophys Res Commun
; 523(3): 795-801, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31954521
3.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476141
4.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23816042
5.
Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities.
Front Oncol
; 13: 1152087, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37342192
6.
Polygenic architecture informs potential vulnerability to drug-induced liver injury.
Nat Med
; 26(10): 1541-1548, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32895570
7.
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Sci Rep
; 10(1): 17081, 2020 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051477
8.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J Med Chem
; 63(3): 1084-1104, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895562
9.
Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.
Commun Biol
; 2: 165, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31069274
10.
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Sci Adv
; 5(5): eaav3660, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31131319
11.
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Nat Commun
; 8(1): 7, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28232751
12.
Motor activity of centromere-associated protein-E contributes to its localization at the center of the midbody to regulate cytokinetic abscission.
Oncotarget
; 7(48): 79964-79980, 2016 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27835888
13.
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.
PLoS One
; 10(12): e0144675, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26649895
14.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
J Med Chem
; 58(20): 8036-53, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26372373
15.
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells.
Nat Commun
; 6: 7668, 2015 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26144554
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