Detalles de la búsqueda
1.
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
Bioorg Med Chem
; 28(22): 115776, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33032189
2.
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists.
Bioorg Med Chem
; 26(8): 1832-1847, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29486951
3.
Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships.
Bioorg Med Chem
; 25(16): 4339-4354, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28662959
4.
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide.
Bioorg Med Chem
; 25(20): 5203-5215, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28807572
5.
TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V1B Receptor.
J Pharmacol Exp Ther
; 357(3): 495-508, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27029585
6.
Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.
Bioorg Med Chem Lett
; 26(15): 3441-6, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27390068
7.
Discovery and in vitro and in vivo profiles of N-ethyl-N-[2-[3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl]ethyl]-2-(2H-1,2,3-triazol-2-yl)-benzamide as a novel class of dual orexin receptor antagonist.
Bioorg Med Chem
; 23(6): 1260-75, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25693785
8.
Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists.
Bioorg Med Chem
; 19(2): 883-93, 2011 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21190859
9.
Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability.
Eur J Med Chem
; 203: 112521, 2020 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32698110
10.
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
ACS Omega
; 5(17): 10145-10159, 2020 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32391502
11.
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
J Med Chem
; 63(23): 14805-14820, 2020 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33210531
12.
Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.
Bioorg Med Chem Lett
; 19(17): 5186-90, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19632840
13.
Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
Bioorg Med Chem Lett
; 19(19): 5531-8, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19726182
14.
Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.
Bioorg Med Chem
; 17(16): 6106-22, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616955
15.
Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.
Bioorg Med Chem Lett
; 18(18): 4997-5001, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18752943
16.
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.
Bioorg Med Chem Lett
; 18(18): 5010-4, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18723347
17.
High-Contrast PET Imaging of Vasopressin V1B Receptors with a Novel Radioligand, 11C-TASP699.
J Nucl Med
; 58(10): 1652-1658, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28450560
18.
Identification of a novel 4-aminomethylpiperidine class of M3 muscarinic receptor antagonists and structural insight into their M3 selectivity.
J Med Chem
; 49(19): 5653-63, 2006 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16970392
19.
Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.
J Med Chem
; 45(4): 984-7, 2002 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11831911
20.
Design of high-quality compound library and open innovation.
Nihon Yakurigaku Zasshi
; 149(4): 180-185, 2017.
Artículo
en Japonés
| MEDLINE | ID: mdl-28381662