Búsqueda | Biblioteca Virtual en Salud

1.

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

Ueki, Kohjiro; Okada, Terumasa; Hu, Jiang; Liew, Chong Wee; Assmann, Anke; Dahlgren, Gabriella M; Peters, Jennifer L; Shackman, Jonathan G; Zhang, Min; Artner, Isabella; Satin, Leslie S; Stein, Roland; Holzenberger, Martin; Kennedy, Robert T; Kahn, C Ronald; Kulkarni, Rohit N.

Nat Genet ; 38(5): 583-8, 2006 May.

Artículo en Inglés | MEDLINE | ID: mdl-16642022

2.

Melanin concentrating hormone is a novel regulator of islet function and growth.

Pissios, Pavlos; Ozcan, Umut; Kokkotou, Efi; Okada, Terumasa; Liew, Chong Wee; Liu, Siming; Peters, Jennifer N; Dahlgren, Gabriella; Karamchandani, Jason; Kudva, Yogish C; Kurpad, Amarnath J; Kennedy, Robert T; Maratos-Flier, Eleftheria; Kulkarni, Rohit N.

Diabetes ; 56(2): 311-9, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17259374

3.

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.

Rosen, Evan D; Kulkarni, Rohit N; Sarraf, Pasha; Ozcan, Umut; Okada, Terumasa; Hsu, Chung-Hsin; Eisenman, Daniel; Magnuson, Mark A; Gonzalez, Frank J; Kahn, C Ronald; Spiegelman, Bruce M.

Mol Cell Biol ; 23(20): 7222-9, 2003 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-14517292

4.

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.

Kulkarni, Rohit N; Almind, Katrine; Goren, H Joseph; Winnay, Jonathon N; Ueki, Kohjiro; Okada, Terumasa; Kahn, C Ronald.

Diabetes ; 52(6): 1528-34, 2003 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-12765966

5.

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

Mori, Yasumichi; Otabe, Shuichi; Dina, Christian; Yasuda, Kazuki; Populaire, Céline; Lecoeur, Cécile; Vatin, Vincent; Durand, Emmanuelle; Hara, Kazuo; Okada, Terumasa; Tobe, Kazuyuki; Boutin, Philippe; Kadowaki, Takashi; Froguel, Philippe.

Diabetes ; 51(4): 1247-55, 2002 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-11916952

6.

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

Hara, Kazuo; Boutin, Philippe; Mori, Yasumichi; Tobe, Kazuyuki; Dina, Christian; Yasuda, Kazuki; Yamauchi, Toshimasa; Otabe, Shuichi; Okada, Terumasa; Eto, Kazuhiro; Kadowaki, Hiroko; Hagura, Ryoko; Akanuma, Yasuo; Yazaki, Yoshio; Nagai, Ryozo; Taniyama, Matsuo; Matsubara, Koichi; Yoda, Madoka; Nakano, Yasuko; Tomita, Motowo; Kimura, Satoshi; Ito, Chikako; Froguel, Philippe; Kadowaki, Takashi.

Diabetes ; 51(2): 536-40, 2002 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-11812766

7.

Altered insulin receptor signalling and ß-cell cycle dynamics in type 2 diabetes mellitus.

Folli, Franco; Okada, Terumasa; Perego, Carla; Gunton, Jenny; Liew, Chong Wee; Akiyama, Masaru; D'Amico, Anna; La Rosa, Stefano; Placidi, Claudia; Lupi, Roberto; Marchetti, Piero; Sesti, Giorgio; Hellerstein, Marc; Perego, Lucia; Kulkarni, Rohit N.

PLoS One ; 6(11): e28050, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-22140505

8.

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

Cheng, Kim; Ho, Kenneth; Stokes, Rebecca; Scott, Christopher; Lau, Sue Mei; Hawthorne, Wayne J; O'Connell, Philip J; Loudovaris, Thomas; Kay, Thomas W; Kulkarni, Rohit N; Okada, Terumasa; Wang, Xiaohui L; Yim, Sun Hee; Shah, Yatrik; Grey, Shane T; Biankin, Andrew V; Kench, James G; Laybutt, D Ross; Gonzalez, Frank J; Kahn, C Ronald; Gunton, Jenny E.

J Clin Invest ; 120(6): 2171-83, 2010 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-20440072

9.

[MODY genes].

Okada, Terumasa; Ito, Yuzuru; Yasuda, Kazuki.

Nihon Rinsho ; 60 Suppl 7: 648-52, 2002 Jul.

Artículo en Japonés | MEDLINE | ID: mdl-12238113

10.

[Systematic hunt for diabetes candidate genes].

Ito, Yuzuru; Okada, Terumasa; Yasuda, Kazuki.

Nihon Rinsho ; 60 Suppl 8: 265-70, 2002 Aug.

Artículo en Japonés | MEDLINE | ID: mdl-12355757

11.

Insulin signaling regulates mitochondrial function in pancreatic beta-cells.

Liu, Siming; Okada, Terumasa; Assmann, Anke; Soto, Jamie; Liew, Chong Wee; Bugger, Heiko; Shirihai, Orian S; Abel, E Dale; Kulkarni, Rohit N.

PLoS One ; 4(11): e7983, 2009 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-19956695

12.

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Okada, Terumasa; Liew, Chong Wee; Hu, Jiang; Hinault, Charlotte; Michael, M Dodson; Krtzfeldt, Jan; Yin, Catherine; Holzenberger, Martin; Stoffel, Markus; Kulkarni, Rohit N.

Proc Natl Acad Sci U S A ; 104(21): 8977-82, 2007 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-17416680

13.

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

Hennige, Anita M; Ozcan, Umut; Okada, Terumasa; Jhala, Ulupi S; Schubert, Markus; White, Morris F; Kulkarni, Rohit N.

Am J Physiol Endocrinol Metab ; 289(2): E337-46, 2005 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-15827066

14.

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Gunton, Jenny E; Kulkarni, Rohit N; Yim, SunHee; Okada, Terumasa; Hawthorne, Wayne J; Tseng, Yu-Hua; Roberson, Russell S; Ricordi, Camillo; O'Connell, Philip J; Gonzalez, Frank J; Kahn, C Ronald.

Cell ; 122(3): 337-49, 2005 Aug 12.

Artículo en Inglés | MEDLINE | ID: mdl-16096055

15.

Tissue-specific targeting of the insulin receptor gene.

Kulkarni, Rohit N; Okada, Terumasa.

Endocrine ; 19(3): 257-66, 2002 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-12624425

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