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1.
Invivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.
Biochem Biophys Res Commun
; 675: 19-25, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37437496
2.
Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.
Molecules
; 22(4)2017 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28406454
3.
Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474.
Cancer Sci
; 106(2): 171-8, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25483727
4.
AMF-26, a novel inhibitor of the Golgi system, targeting ADP-ribosylation factor 1 (Arf1) with potential for cancer therapy.
J Biol Chem
; 287(6): 3885-97, 2012 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-22158626
5.
Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors.
Cell Death Dis
; 14(2): 169, 2023 02 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36849535
6.
Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors.
Biol Pharm Bull
; 35(9): 1607-13, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22975517
7.
Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety.
RSC Adv
; 12(25): 15728-15739, 2022 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35685710
8.
Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo.
Cancer Sci
; 102(6): 1176-80, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21352422
9.
Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest.
Biochem Biophys Res Commun
; 379(1): 104-9, 2009 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-19094964
10.
Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines.
Oncotarget
; 9(80): 35141-35161, 2018 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30416685
11.
Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors.
Oncotarget
; 9(2): 1641-1655, 2018 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29416720
12.
A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I.
Pharmacol Res Perspect
; 4(4): e00246, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28116099
13.
M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers.
Cancer Res
; 76(13): 3895-903, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27197184
14.
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
J Med Chem
; 59(8): 3650-60, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27088648
15.
Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead.
Eur J Med Chem
; 86: 684-9, 2014 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-25226228
16.
ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.
Eur J Cancer
; 48(6): 936-43, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22088482
17.
Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status: in silico and biological evaluations.
Cancer Res
; 70(12): 4982-94, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20530683
18.
Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.
Eur J Cancer
; 45(5): 857-65, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19144509
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