Detalles de la búsqueda
1.
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity.
Int J Mol Sci
; 24(18)2023 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37762006
2.
Trisubstituted 1,3,5-Triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo.
Molecules
; 28(10)2023 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37241939
3.
2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule.
Int J Mol Sci
; 23(8)2022 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35456915
4.
Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity-In Vitro and In Vivo Studies.
Molecules
; 27(3)2022 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35164136
5.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Molecules
; 28(1)2022 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615435
6.
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Bioorg Chem
; 114: 105129, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34217977
7.
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
Int J Mol Sci
; 22(19)2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34639113
8.
Biphenylalkoxyamine Derivatives-Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity.
Molecules
; 26(12)2021 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34208297
9.
8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation.
Bioorg Chem
; 101: 104033, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32629282
10.
Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors.
Int J Mol Sci
; 21(10)2020 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32408504
11.
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Bioorg Med Chem
; 27(7): 1195-1210, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30808606
12.
Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.
Bioorg Chem
; 91: 103071, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31362197
13.
4-tert-Pentylphenoxyalkyl derivatives - Histamine H3 receptor ligands and monoamine oxidase B inhibitors.
Bioorg Med Chem Lett
; 28(23-24): 3596-3600, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30404719
14.
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
J Med Chem
; 67(2): 1580-1610, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38190615
15.
Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.
Biomolecules
; 13(7)2023 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37509114
16.
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Eur J Med Chem
; 260: 115756, 2023 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37657272
17.
Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.
J Med Chem
; 66(21): 14928-14947, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37797083
18.
Dual Targeting Ligands-Histamine H3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity-In Vitro and In Vivo Evaluation.
Pharmaceutics
; 14(10)2022 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36297622
19.
Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Eur J Med Chem
; 236: 114329, 2022 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35397400
20.
Novel, Dual Target-Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B.
ChemMedChem
; 15(9): 772-786, 2020 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32162782