Detalles de la búsqueda
1.
Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones.
J Org Chem
; 77(8): 3887-906, 2012 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22458369
2.
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.
Bioorg Med Chem Lett
; 19(2): 424-7, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19062275
3.
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J Med Chem
; 50(4): 611-26, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253678
4.
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
J Med Chem
; 50(4): 627-40, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253679
5.
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
J Med Chem
; 59(6): 2794-809, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26942860
6.
Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
J Med Chem
; 58(13): 5189-207, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25970324
7.
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J Med Chem
; 53(17): 6368-77, 2010 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20684549
8.
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Cancer Res
; 70(23): 9846-54, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20935223
9.
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorg Med Chem Lett
; 17(10): 2886-9, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17350837
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