Detalles de la búsqueda
1.
Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 68(1): e0071723, 2024 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38018963
2.
Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33766889
3.
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development.
PLoS Pathog
; 17(2): e1009225, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33596266
4.
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 66(9): e0066922, 2022 09 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36005813
5.
Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9).
Bioorg Med Chem Lett
; 75: 128808, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35609741
6.
In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.
Antimicrob Agents Chemother
; 60(8): 4830-9, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27246784
7.
Synthesis of amino heterocycle aspartyl protease inhibitors.
Org Biomol Chem
; 14(22): 4970-85, 2016 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27143279
8.
Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).
Bioorg Med Chem Lett
; 25(17): 3630-5, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26152426
9.
Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).
Bioorg Med Chem Lett
; 25(17): 3636-43, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26141771
10.
Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Bioorg Med Chem Lett
; 25(11): 2409-15, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25911300
11.
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett
; 25(12): 2473-8, 2015 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25978963
12.
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg Med Chem Lett
; 25(9): 1831-5, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25851938
13.
Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.
Antimicrob Agents Chemother
; 58(4): 2387-92, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24514098
14.
Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees.
PLoS Pathog
; 8(8): e1002895, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22952447
15.
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease.
Microbiol Spectr
; 12(4): e0358623, 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38391232
16.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis
; 10(5): 1679-1695, 2024 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38581700
17.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem
; 67(5): 3935-3958, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38365209
18.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Antimicrob Agents Chemother
; 56(8): 4161-7, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22615282
19.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23084906
20.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23021993