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1.
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J Biol Chem
; 287(49): 41245-57, 2012 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23048024
2.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
Bioorg Med Chem Lett
; 22(18): 5919-23, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22889803
3.
Aminoimidazoles as BACE-1 inhibitors: the challenge to achieve in vivo brain efficacy.
Bioorg Med Chem Lett
; 22(5): 1854-9, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22325942
4.
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
J Med Chem
; 50(24): 5903-11, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17985861
5.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
J Med Chem
; 50(24): 5912-25, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17985862
6.
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Sci Rep
; 6: 38644, 2016 12 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27995962
7.
Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease.
PLoS One
; 9(8): e104001, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25089527
8.
New aminoimidazoles as ß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.
J Med Chem
; 55(21): 9297-311, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23017051
9.
Design and synthesis of ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of ß-amyloid peptides.
J Med Chem
; 55(21): 9346-61, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22924815
10.
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
Curr Top Med Chem
; 7(16): 1600-29, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17979771
11.
Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3.
J Biol Chem
; 279(7): 5597-603, 2004 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-14627696
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