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1.
Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs.
PLoS Genet
; 19(10): e1011014, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37906604
2.
A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals.
PLoS Genet
; 16(8): e1008981, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32745133
3.
The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum.
PLoS Pathog
; 13(9): e1006589, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28953979
4.
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation.
Nucleic Acids Res
; 44(20): 9719-9732, 2016 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27471030
5.
TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1.
Biochim Biophys Acta
; 1863(11): 2668-2680, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27526673
6.
TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor.
Biochim Biophys Acta
; 1853(10 Pt A): 2492-505, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26094770
7.
Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function.
Cell Immunol
; 280(1): 68-75, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23261831
8.
Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib.
Cancers (Basel)
; 13(10)2021 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34066165
9.
TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter.
Biochim Biophys Acta Gene Regul Mech
; 1861(3): 271-281, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29378327
10.
Mammalian Pseudokinase TRIB3 in Normal Physiology and Disease: Charting the Progress in Old and New Avenues.
Curr Protein Pept Sci
; 18(8): 819-842, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28393700
11.
Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis.
Sci Rep
; 7(1): 6684, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28751721
12.
Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet.
PLoS One
; 9(4): e94691, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24732777
13.
Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.
PLoS One
; 5(12): e15716, 2010 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21203563
14.
Human TRB3 is upregulated in stressed cells by the induction of translationally efficient mRNA containing a truncated 5'-UTR.
Gene
; 444(1-2): 24-32, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19505541
15.
Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements.
J Biol Chem
; 284(32): 21241-8, 2009 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-19509279
16.
TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.
Exp Cell Res
; 313(16): 3556-67, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17707795
17.
Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.
Biochem Biophys Res Commun
; 330(1): 210-8, 2005 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-15781252
18.
Mouse NIPK interacts with ATF4 and affects its transcriptional activity.
Exp Cell Res
; 286(2): 308-20, 2003 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-12749859
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