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1.
Modular, stereocontrolled Cß-H/Cα-C activation of alkyl carboxylic acids.
Proc Natl Acad Sci U S A
; 116(18): 8721-8727, 2019 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-30996125
2.
Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer.
Anal Chem
; 89(13): 6969-6975, 2017 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28520396
3.
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.
J Biol Chem
; 290(32): 19403-22, 2015 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26055715
4.
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.
J Virol
; 88(20): 11886-98, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25100843
5.
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.
Bioorg Med Chem Lett
; 25(22): 5072-7, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26592814
6.
Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization.
Tetrahedron Lett
; 56(23): 3314-3317, 2015 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-26185337
7.
BACE1 (ß-secretase) inhibitors for the treatment of Alzheimer's disease.
Chem Soc Rev
; 43(19): 6765-813, 2014 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24691405
8.
Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.
Org Biomol Chem
; 12(35): 6842-54, 2014 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25050776
9.
Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Nat Commun
; 14(1): 4930, 2023 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37582753
10.
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
J Med Chem
; 63(9): 4867-4879, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32348139
11.
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
J Med Chem
; 61(10): 4561-4577, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29763303
12.
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.
ChemMedChem
; 13(8): 803-815, 2018 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29437300
13.
Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Nat Commun
; 14(1): 7589, 2023 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37989745
14.
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
J Med Chem
; 60(10): 4267-4278, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28418652
15.
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
Elife
; 62017 10 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29039736
16.
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.
J Med Chem
; 59(11): 5172-208, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26799988
17.
Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.
J Med Chem
; 59(14): 6826-37, 2016 07 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27389367
18.
Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.
J Med Chem
; 58(13): 5334-43, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26107245
19.
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.
J Med Chem
; 58(17): 6994-7006, 2015 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26306007
20.
A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.
mBio
; 5(2): e00047-14, 2014 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24667706