Detalles de la búsqueda
1.
NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.
EMBO J
; 37(16)2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29875132
2.
A novel orally available small molecule that inhibits hepatitis B virus expression.
J Hepatol
; 68(3): 412-420, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29079285
3.
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
J Pharmacol Exp Ther
; 365(2): 237-248, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29453199
4.
An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.
Regul Toxicol Pharmacol
; 95: 339-347, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29635059
5.
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Bioorg Med Chem Lett
; 26(20): 5092-5097, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27658368
6.
A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides.
Drug Metab Dispos
; 43(11): 1711-7, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26276581
7.
Potential confounding effects of benzyl alcohol as a formulation excipient support the elimination of the abnormal toxicity test from pharmacopoeias.
Regul Toxicol Pharmacol
; 73(2): 509-14, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26449397
8.
On the Waring problem for polynomial rings.
Proc Natl Acad Sci U S A
; 109(15): 5600-2, 2012 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22460787
9.
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.
J Med Chem
; 66(6): 4253-4270, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36896968
10.
Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.
J Med Chem
; 66(20): 14116-14132, 2023 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37801325
11.
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(8): 2609-13, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20231096
12.
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J Med Chem
; 63(13): 6876-6897, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32530624
13.
The PAMPA technique as a HTS tool for partition coefficients determination in different solvent/water systems.
Eur J Pharm Sci
; 35(1-2): 68-75, 2008 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-18620049
14.
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
J Med Chem
; 50(4): 742-8, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17300161
15.
An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.
Bioanalysis
; 9(3): 297-312, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28111961
16.
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.
J Med Chem
; 60(8): 3352-3371, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28339215
17.
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
J Med Chem
; 49(13): 3948-54, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789751
18.
Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy.
Nephron
; 132(1): 59-69, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26646377
19.
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.
ChemMedChem
; 11(2): 179-89, 2016 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26228928
20.
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
J Med Chem
; 58(20): 8054-65, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26403853