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1.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25459880
2.
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Bioorg Med Chem
; 23(21): 7000-6, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26455654
3.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551024
4.
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
Cell Chem Biol
; 26(11): 1559-1572.e9, 2019 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31543462
5.
Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation.
ACS Infect Dis
; 5(10): 1738-1753, 2019 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31373203
6.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31749904
7.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ACS Med Chem Lett
; 10(6): 857-862, 2019 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31223438
8.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31265286
9.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31013427
10.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30344914
11.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28151659
12.
A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.
Methods Mol Biol
; 1439: 207-26, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27316998
13.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26854747
14.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27109867
15.
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
ACS Med Chem Lett
; 4(12): 1238-43, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900635
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