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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Bioorg Med Chem Lett
; 26(23): 5663-5668, 2016 12 01.
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en Inglés
| MEDLINE | ID: mdl-27836401
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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
J Pharmacol Exp Ther
; 336(1): 165-77, 2011 Jan.
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| MEDLINE | ID: mdl-20947638
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