Búsqueda | Biblioteca Virtual en Salud

1.

An improved zinc-finger nuclease architecture for highly specific genome editing.

Miller, Jeffrey C; Holmes, Michael C; Wang, Jianbin; Guschin, Dmitry Y; Lee, Ya-Li; Rupniewski, Igor; Beausejour, Christian M; Waite, Adam J; Wang, Nathaniel S; Kim, Kenneth A; Gregory, Philip D; Pabo, Carl O; Rebar, Edward J.

Nat Biotechnol ; 25(7): 778-85, 2007 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-17603475

2.

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

Snowden, Andrew W; Gregory, Philip D; Case, Casey C; Pabo, Carl O.

Curr Biol ; 12(24): 2159-66, 2002 Dec 23.

Artículo en Inglés | MEDLINE | ID: mdl-12498693

3.

Drug discovery with engineered zinc-finger proteins.

Jamieson, Andrew C; Miller, Jeffrey C; Pabo, Carl O.

Nat Rev Drug Discov ; 2(5): 361-8, 2003 May.

Artículo en Inglés | MEDLINE | ID: mdl-12750739

4.

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors.

Snowden, Andrew W; Zhang, Lei; Urnov, Fyodor; Dent, Carolyn; Jouvenot, Yann; Zhong, Xiaohong; Rebar, Edward J; Jamieson, Andrew C; Zhang, H Steven; Tan, Siyuan; Case, Casey C; Pabo, Carl O; Wolffe, Alan P; Gregory, Philip D.

Cancer Res ; 63(24): 8968-76, 2003 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-14695215

5.

Constraints for zinc finger linker design as inferred from X-ray crystal structure of tandem Zif268-DNA complexes.

Peisach, Ezra; Pabo, Carl O.

J Mol Biol ; 330(1): 1-7, 2003 Jun 27.

Artículo en Inglés | MEDLINE | ID: mdl-12818197

6.

Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors.

Morton, Magda F; Liu, Pei-Qi; Reik, Andreas; de la Rosa, Ragan; Mendel, Matthew; Li, Xiao-Yong; Case, Casey; Pabo, Carl; Moreno, Veronica; Pyati, Jayashree; Shankley, Nigel P.

Regul Pept ; 129(1-3): 227-32, 2005 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-15927720

7.

Cell lines for drug discovery: elevating target-protein levels using engineered transcription factors.

Liu, Pei-Qi; Morton, Magda F; Reik, Andreas; de la Rosa, Ragan; Mendel, Matthew C; Li, Xiao-Yong; Case, Casey C; Pabo, Carl O; Moreno, Veronica; Kempf, Ashley; Pyati, Jayashree; Shankley, Nigel P.

J Biomol Screen ; 9(1): 44-51, 2004 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-15006148

8.

Specificity by design.

Pabo, Carl O.

Nat Biotechnol ; 24(8): 954-5, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16900141

9.

Structure of a designed dimeric zinc finger protein bound to DNA.

Wolfe, Scot A; Grant, Robert A; Pabo, Carl O.

Biochemistry ; 42(46): 13401-9, 2003 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-14621985

10.

Engineered zinc finger proteins for controlling stem cell fate.

Bartsevich, Victor V; Miller, Jeffrey C; Case, Casey C; Pabo, Carl O.

Stem Cells ; 21(6): 632-7, 2003.

Artículo en Inglés | MEDLINE | ID: mdl-14595122

11.

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection.

Hurt, Jessica A; Thibodeau, Stacey A; Hirsh, Andrew S; Pabo, Carl O; Joung, J Keith.

Proc Natl Acad Sci U S A ; 100(21): 12271-6, 2003 Oct 14.

Artículo en Inglés | MEDLINE | ID: mdl-14527993

12.

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands.

Nguyen-Hackley, Doan H; Ramm, Elizabeth; Taylor, Christina M; Joung, J Keith; Dervan, Peter B; Pabo, Carl O.

Biochemistry ; 43(13): 3880-90, 2004 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-15049695

13.

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

Tan, Siyuan; Guschin, Dmitry; Davalos, Albert; Lee, Ya-Li; Snowden, Andrew W; Jouvenot, Yann; Zhang, H Steven; Howes, Katherine; McNamara, Andrew R; Lai, Albert; Ullman, Chris; Reynolds, Lindsey; Moore, Michael; Isalan, Mark; Berg, Lutz-Peter; Campos, Bradley; Qi, Hong; Spratt, S Kaye; Case, Casey C; Pabo, Carl O; Campisi, Judith; Gregory, Philip D.

Proc Natl Acad Sci U S A ; 100(21): 11997-2002, 2003 Oct 14.

Artículo en Inglés | MEDLINE | ID: mdl-14514889

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