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1.
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.
Molecules
; 25(17)2020 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32899288
2.
Potent GH20 N-Acetyl-ß-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols.
Molecules
; 23(3)2018 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29558439
3.
A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal ß-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.
Bioorg Med Chem Lett
; 27(15): 3431-3435, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28600215
4.
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful ß-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal ß-galactosidase.
Bioorg Med Chem Lett
; 26(5): 1438-42, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26838810
5.
Fluorous iminoalditols act as effective pharmacological chaperones against gene products from GLB1 alleles causing GM1-gangliosidosis and Morquio B disease.
J Inherit Metab Dis
; 35(3): 495-503, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22033734
6.
DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts.
Mol Genet Metab
; 100(3): 262-8, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20409738
7.
N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal ß-galactosidase mutant.
Carbohydr Res
; 443-444: 15-22, 2017 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28319682
8.
A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.
Carbohydr Res
; 442: 31-40, 2017 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28288345
9.
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable ß-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal ß-galactosidase mutant R201C.
Carbohydr Res
; 429: 71-80, 2016 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27063389
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