Detalles de la búsqueda
1.
Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.
J Chromatogr A
; 1679: 463385, 2022 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35933770
2.
Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins.
J Chromatogr A
; 1655: 462479, 2021 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34461348
3.
Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments.
J Chromatogr A
; 1648: 462181, 2021 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33989897
4.
Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.
Biotechnol Prog
; 37(3): e3119, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33373106
5.
Chromatographic behavior of bivalent bispecific antibodies on hydrophobic interaction chromatography columns.
J Chromatogr A
; 1617: 460836, 2020 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31973931
6.
Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model.
J Chromatogr A
; 1601: 121-132, 2019 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31056270
7.
Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. II. Biomolecular perspectives.
J Chromatogr A
; 1601: 133-144, 2019 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31054833
8.
Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions.
MAbs
; 11(4): 789-802, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30913985
9.
Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.
Biotechnol Prog
; 35(1): e2732, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30320962
10.
Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups.
J Chromatogr A
; 1181(1-2): 83-94, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18194806
11.
Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics.
J Chromatogr A
; 1554: 45-60, 2018 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29685337
12.
pH transitions in cation exchange chromatographic columns containing weak acid groups.
J Chromatogr A
; 1142(1): 19-31, 2007 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-16978635
13.
Comparison of strong anion-exchangers for the purification of a PEGylated protein.
J Chromatogr A
; 1147(2): 172-82, 2007 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17346720
14.
Separation of antibody monomer-dimer mixtures by frontal analysis.
J Chromatogr A
; 1500: 96-104, 2017 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28420529
15.
Camelid VH H affinity ligands enable separation of closely related biopharmaceuticals.
Biotechnol J
; 12(2)2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27677057
16.
Adsorption equilibrium and kinetics of monomer-dimer monoclonal antibody mixtures on a cation exchange resin.
J Chromatogr A
; 1402: 46-59, 2015 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26028510
17.
Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin.
J Chromatogr A
; 1325: 171-8, 2014 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24369997
18.
Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity.
J Chromatogr A
; 1362: 180-5, 2014 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25193170
19.
Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin.
Biotechnol Prog
; 30(6): 1380-9, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139260
20.
Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates.
J Chromatogr A
; 1216(27): 5256-64, 2009 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-19497581