Detalles de la búsqueda
1.
Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates.
J Chem Inf Model
; 63(3): 846-855, 2023 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36719788
2.
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.
Bioorg Med Chem
; 56: 116588, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35030421
3.
Human topoisomerase inhibition and DNA/BSA binding of Ru(II)-SCAR complexes as potential anticancer candidates for oral application.
Biometals
; 30(3): 321-334, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28303361
4.
Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study.
Antimicrob Agents Chemother
; 60(4): 2492-8, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26883698
5.
Consideration of vendor-related differences in hepatic metabolic stability data to optimize early ADME screening in drug discovery.
SLAS Discov
; 29(1): 34-39, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37573009
6.
Automated measurement of transepithelial electrical resistance (TEER) in 96-well transwells using ECIS TEER96: Single and multiple time point assessments.
SLAS Technol
; 29(1): 100116, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37923083
7.
Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug.
Front Pharmacol
; 14: 1099425, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37113753
8.
In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis.
Biomed Pharmacother
; 168: 115178, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37890204
9.
Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates.
Front Pharmacol
; 14: 1291246, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38108064
10.
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury.
Redox Biol
; 60: 102611, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36709665
11.
Pharmacokinetic and safety evaluation of the use of ciprofloxacin on an isoniazid-rifampicin regimen in rabbits.
Biopharm Drug Dispos
; 33(9): 501-9, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23007681
12.
Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform.
Front Pharmacol
; 13: 899536, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35847040
13.
Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment.
Front Pharmacol
; 13: 918083, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36052127
14.
NOX2 inhibitor GSK2795039 metabolite identification towards drug optimization.
J Pharm Biomed Anal
; 201: 114102, 2021 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33992989
15.
Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies.
J Biomol Struct Dyn
; 39(3): 1017-1028, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-32028848
16.
Metabolism and pharmacokinetics characterization of metarrestin in multiple species.
Cancer Chemother Pharmacol
; 85(4): 805-816, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32185484
17.
Parkinson's Disease: A Review from Pathophysiology to Treatment.
Mini Rev Med Chem
; 20(9): 754-767, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31686637
18.
Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.
J Med Chem
; 63(8): 4256-4292, 2020 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32212730
19.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem
; 63(19): 10984-11011, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32902275
20.
Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).
Front Pharmacol
; 10: 234, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31068801