Detalles de la búsqueda
1.
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 59(1): 693-7, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25348525
2.
Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.
Antimicrob Agents Chemother
; 59(2): 753-62, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25385118
3.
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Elife
; 112022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35289746
4.
Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists.
Bioorg Med Chem Lett
; 19(15): 4299-302, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19505824
5.
Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases.
J Med Chem
; 61(21): 9551-9567, 2018 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30351000
6.
Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.
PLoS One
; 12(4): e0176088, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28423019
7.
Correction: The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Elife
; 112022 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36063387
8.
N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.
ChemMedChem
; 11(7): 687-701, 2016 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26934341
9.
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
J Med Chem
; 59(23): 10479-10497, 2016 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933955
10.
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
Eur J Med Chem
; 112: 252-257, 2016 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26900657
11.
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
J Med Chem
; 58(2): 613-24, 2015 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-25517015
12.
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
J Med Chem
; 58(16): 6448-55, 2015 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-26222445
13.
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
J Med Chem
; 58(11): 4573-80, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25906200
14.
Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
J Med Chem
; 47(25): 6326-37, 2004 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15566302
15.
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.
J Med Chem
; 57(4): 1276-88, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24450589
16.
α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
Int J Biochem Cell Biol
; 45(8): 1748-57, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23726834
17.
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Eur J Med Chem
; 46(10): 4946-56, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21871695
18.
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
PLoS One
; 5(9)2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20824144
19.
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
J Med Chem
; 53(19): 6912-22, 2010 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-20825218
20.
PDE4 inhibitors: a review of current developments (2005 - 2009).
Expert Opin Ther Pat
; 19(11): 1501-19, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19832118