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1.
Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.
Bioorg Med Chem Lett
; 27(13): 3030-3035, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28526367
2.
Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery.
Mol Pharm
; 13(2): 609-20, 2016 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26696327
3.
Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
Bioorg Med Chem Lett
; 25(13): 2679-85, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25980912
4.
Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
Bioorg Med Chem Lett
; 25(22): 5155-62, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26475521
5.
Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time.
J Comput Aided Mol Des
; 29(9): 795-807, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25697964
6.
Hydantoin based inhibitors of MMP13--discovery of AZD6605.
Bioorg Med Chem Lett
; 23(16): 4705-12, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23810497
7.
In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.
Chem Res Toxicol
; 25(8): 1616-32, 2012 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22646477
8.
Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2.
Bioorg Med Chem Lett
; 22(1): 271-7, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22153941
9.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22858142
10.
Addressing personal protective equipment (PPE) decontamination: Methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit.
Infect Control Hosp Epidemiol
; 43(7): 876-885, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34016200
11.
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
Bioorg Med Chem Lett
; 21(11): 3301-6, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21536437
12.
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 19(6): 1658-61, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19231183
13.
Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
Bioorg Med Chem Lett
; 19(16): 4832-5, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19574045
14.
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18676144
15.
Decontamination and reuse of personal protective masks and respirators in healthcare: Human-centered investigation and implementation considerations.
Hum Factors Health
; 1: 100003, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35620552
16.
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.
J Med Chem
; 48(2): 392-402, 2005 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15658853
17.
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
J Med Chem
; 56(5): 2125-38, 2013 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23394205
18.
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
J Med Chem
; 56(5): 2059-73, 2013 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23394218
19.
Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background.
Mol Cancer Ther
; 11(4): 873-87, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22294718
20.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22742641