Detalles de la búsqueda
1.
Connecting GSK-3ß Inhibitory Activity with IKK-ß or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors.
Molecules
; 29(11)2024 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38893493
2.
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and ß-amyloid inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 88-89: 117333, 2023 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37236021
3.
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.
Bioorg Med Chem
; 96: 117535, 2023 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37956505
4.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.
Int J Mol Sci
; 24(11)2023 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298087
5.
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 35(1): 1944-1952, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33092411
6.
Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity.
Arch Pharm (Weinheim)
; 352(7): e1900041, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31162703
7.
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.
Molecules
; 23(2)2018 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29414887
8.
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.
Bioorg Med Chem Lett
; 26(16): 4140-5, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27445168
9.
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.
Molecules
; 21(4): 410, 2016 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27023510
10.
SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD.
Acta Pol Pharm
; 72(4): 737-45, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26647631
11.
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Eur J Med Chem
; 249: 115135, 2023 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36696766
12.
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, ß-secretase, and amyloid ß aggregation as potential treatment of Alzheimer's disease.
Eur J Med Chem
; 261: 115832, 2023 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37837674
13.
Dual Inhibitors of Amyloid-ß and Tau Aggregation with Amyloid-ß Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.
ACS Chem Neurosci
; 12(11): 2057-2068, 2021 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34019757
14.
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
Eur J Med Chem
; 225: 113783, 2021 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34461507
15.
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Eur J Med Chem
; 218: 113397, 2021 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33838585
16.
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
Eur J Med Chem
; 187: 111916, 2020 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31812794
17.
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
J Med Chem
; 62(24): 11416-11422, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31724859
18.
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.
ACS Chem Neurosci
; 9(5): 1074-1094, 2018 05 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29345897
19.
Advances toward multifunctional cholinesterase and ß-amyloid aggregation inhibitors.
Future Med Chem
; 9(15): 1835-1854, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28925729
20.
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Eur J Med Chem
; 125: 676-695, 2017 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27721153