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1.
Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides.
Int J Mol Sci
; 23(23)2022 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36499418
2.
Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.
Int J Mol Sci
; 22(4)2021 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33578647
3.
Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci
; 22(15)2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34360555
4.
Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase.
Bioorg Med Chem
; 28(17): 115645, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32773091
5.
Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase.
Bioorg Med Chem
; 28(15): 115580, 2020 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32631562
6.
Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules
; 25(20)2020 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33081246
7.
LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1.
Pharmacol Res
; 122: 66-77, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28571892
8.
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
Bioorg Med Chem Lett
; 25(5): 1124-8, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25655718
9.
Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases.
Signal Transduct Target Ther
; 8(1): 148, 2023 04 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37029108
10.
Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol
; 5(1): 883, 2022 08 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36038645
11.
Detailed resume of RNA m6A demethylases.
Acta Pharm Sin B
; 12(5): 2193-2205, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35646549
12.
Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur J Med Chem
; 211: 113021, 2021 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33248851
13.
Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
ACS Chem Biol
; 15(2): 407-415, 2020 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31869198
14.
Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases.
Antibiotics (Basel)
; 8(4)2019 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31600972
15.
Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur J Med Chem
; 173: 154-166, 2019 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30995568
16.
Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
Eur J Med Chem
; 174: 252-264, 2019 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31048140
17.
Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases.
Eur J Med Chem
; 148: 384-396, 2018 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29477072
18.
Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.
Eur J Med Chem
; 143: 1535-1542, 2018 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29126726
19.
Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents.
J Med Chem
; 58(4): 1705-16, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25610955
20.
Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents.
Eur J Med Chem
; 86: 368-80, 2014 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-25180925