Detalles de la búsqueda
1.
Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam.
Drug Metab Dispos
; 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38653501
2.
PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.
Drug Metab Dispos
; 2023 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37879848
3.
Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles.
Drug Metab Dispos
; 51(3): 276-284, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36460477
4.
Drug Design and Success of Prospective Mouse In Vitro-In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint).
Mol Pharm
; 20(7): 3438-3459, 2023 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37235687
5.
A Machine Learning Framework to Improve Rat Clearance Predictions and Inform Physiologically Based Pharmacokinetic Modeling.
Mol Pharm
; 20(10): 5052-5065, 2023 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37713584
6.
Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.
Drug Metab Dispos
; 50(3): 214-223, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34937801
7.
Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes.
Drug Metab Dispos
; 50(5): 566-575, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35246464
8.
Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds.
Mol Pharm
; 19(11): 3858-3868, 2022 11 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36150125
9.
Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery.
Mol Pharm
; 19(7): 2203-2216, 2022 07 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35476457
10.
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist.
Xenobiotica
; 52(8): 855-867, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-36004550
11.
Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes.
Drug Metab Dispos
; 49(9): 760-769, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34187837
12.
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.
Drug Metab Dispos
; 48(10): 849-860, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32739889
13.
Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.
Drug Metab Dispos
; 47(2): 124-134, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30478159
14.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos
; 47(10): 1206-1221, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31439574
15.
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
Br J Clin Pharmacol
; 85(1): 100-113, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30198595
16.
A novel orally available small molecule that inhibits hepatitis B virus expression.
J Hepatol
; 68(3): 412-420, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29079285
17.
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
J Pharmacol Exp Ther
; 365(2): 237-248, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29453199
18.
Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.
J Pharmacol Exp Ther
; 360(1): 164-173, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27821711
19.
Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.
Pharm Res
; 33(10): 2565-79, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27469324
20.
Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.
Pharm Res
; 33(5): 1115-25, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26786016