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1.
In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
Nucleic Acids Res
; 43(18): 8638-50, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26338776
2.
Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment.
Nucleic Acid Ther
; 31(1): 7-20, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33054599
3.
Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Chem Res Toxicol
; 22(4): 717-25, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19338340
4.
Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
Mol Ther Nucleic Acids
; 8: 383-394, 2017 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28918038
5.
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.
Adv Drug Deliv Rev
; 71: 15-33, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24530633
6.
Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations.
Nucleic Acid Ther
; 22(4): 246-54, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22809313
7.
Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.
PLoS One
; 5(9): e12733, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20856801
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