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1.
Effects of sarizotan in animal models of ADHD: challenging pharmacokinetic-pharmacodynamic relationships.
J Neural Transm (Vienna)
; 122(9): 1221-38, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25796190
2.
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.
J Neural Transm (Vienna)
; 118(12): 1703-16, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21161716
3.
Inhalational Anesthetics Do Not Deteriorate Amyloid-ß-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level.
J Alzheimers Dis
; 84(3): 1193-1218, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34657881
4.
Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
Bioorg Med Chem
; 17(15): 5708-15, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19574055
5.
The anaesthetic xenon partially restores an amyloid beta-induced impairment in murine hippocampal synaptic plasticity.
Neuropharmacology
; 151: 21-32, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940537
6.
Positive and negative modulation of group I metabotropic glutamate receptors.
J Med Chem
; 51(3): 634-47, 2008 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18173231
7.
Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.
Eur J Pharmacol
; 566(1-3): 11-9, 2007 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-17466293
8.
MRZ-99030 - A novel modulator of Aß aggregation: I - Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD).
Neuropharmacology
; 92: 158-69, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25634238
9.
MRZ-99030 - A novel modulator of Aß aggregation: II - Reversal of Aß oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice.
Neuropharmacology
; 92: 170-82, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25637092
10.
Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.
Eur J Pharmacol
; 466(1-2): 99-111, 2003 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12679146
11.
GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats.
ACS Chem Neurosci
; 4(5): 808-16, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23611155
12.
Searching for drug scaffolds with 3D pharmacophores and neural network ensembles.
Angew Chem Int Ed Engl
; 46(28): 5336-9, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17604383
13.
Virtual screening for selective allosteric mGluR1 antagonists and structure-activity relationship investigations for coumarine derivatives.
ChemMedChem
; 2(12): 1763-73, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17868161
14.
3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.
Hippocampus
; 16(10): 834-42, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16897723
15.
Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists.
ChemMedChem
; 1(10): 1066-8, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16986201
16.
New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening.
Chembiochem
; 6(4): 620-5, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15744765
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