Detalles de la búsqueda
1.
HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats.
Neurochem Res
; 48(3): 839-845, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36350432
2.
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold.
Bioorg Chem
; 139: 106737, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37482048
3.
An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.
Bioorg Chem
; 121: 105695, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35228010
4.
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Int J Mol Sci
; 23(19)2022 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36232749
5.
New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1'-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT1A/5-HT7 Affinity and Its Antidepressant-like Activity.
Molecules
; 27(21)2022 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364104
6.
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
Int J Mol Sci
; 22(19)2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34639113
7.
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Molecules
; 25(17)2020 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32854402
8.
Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.
Cent Eur J Immunol
; 45(1): 37-47, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32425678
9.
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Bioorg Med Chem
; 27(18): 4163-4173, 2019 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31383628
10.
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.
Int J Mol Sci
; 20(14)2019 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31336820
11.
Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.
Molecules
; 24(24)2019 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31817628
12.
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.
Bioorg Med Chem Lett
; 28(5): 878-883, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439902
13.
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.
Molecules
; 23(10)2018 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30282913
14.
Synthesis and biological investigations of 3ß-aminotropane arylamide derivatives with atypical antipsychotic profile.
Med Chem Res
; 27(8): 1906-1928, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30100693
15.
The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties.
Bioorg Med Chem
; 25(14): 3638-3648, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28529043
16.
Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile.
Bioorg Med Chem
; 25(10): 2789-2799, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28391970
17.
The mRNA expression levels of uncoupling proteins 1 and 2 in mononuclear cells from patients with metabolic disorders: obesity and type 2 diabetes mellitus.
Postepy Hig Med Dosw (Online)
; 71(0): 895-900, 2017 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29151065
18.
N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.
Bioorg Med Chem
; 24(2): 130-9, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26706111
19.
Synthesis and biological investigation of new equatorial (ß) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
Bioorg Med Chem
; 24(18): 3994-4007, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27377863
20.
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
J Enzyme Inhib Med Chem
; 31(sup3): 10-24, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27353547