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1.
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior.
Physiol Rev
; 101(3): 1083-1176, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33118864
2.
All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation.
Biophys J
; 118(10): 2596-2611, 2020 05 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32298635
3.
Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities.
J Mol Cell Cardiol
; 142: 24-38, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32251669
4.
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Toxicol Appl Pharmacol
; 390: 114883, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31981640
5.
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.
J Mol Cell Cardiol
; 96: 72-81, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26385634
6.
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.
Europace
; 18(9): 1287-98, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26622055
7.
Recurrent intradialytic paroxysmal atrial fibrillation: hypotheses on onset mechanisms based on clinical data and computational analysis.
Europace
; 16(3): 396-404, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24569894
8.
Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti-seizure medication: Levetiracetam case study.
Pharmacol Res Perspect
; 11(1): e01059, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36748725
9.
Advancing the 3Rs: innovation, implementation, ethics and society.
Front Vet Sci
; 10: 1185706, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37396988
10.
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction.
Front Toxicol
; 4: 992650, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36278026
11.
Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions.
Front Pharmacol
; 12: 604713, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33841140
12.
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Clin Transl Sci
; 14(3): 1133-1146, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33620150
13.
Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling.
Front Physiol
; 11: 314, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32351400
14.
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Clin Pharmacol Ther
; 107(1): 102-111, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31709525
15.
Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.
Br J Pharmacol
; 176(19): 3819-3833, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31271649
16.
Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.
Front Pharmacol
; 10: 1643, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32082155
17.
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.
Elife
; 82019 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31868580
18.
Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach.
Heart Rhythm
; 14(11): 1704-1712, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28756098
19.
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity.
Front Physiol
; 8: 668, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28955244
20.
Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.
Prog Biophys Mol Biol
; 120(1-3): 115-27, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26701222