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1.
Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model.
Hum Mol Genet
; 2024 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38776957
2.
Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.
J Proteome Res
; 19(1): 194-203, 2020 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31657576
3.
Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease.
Biochem Biophys Res Commun
; 527(3): 676-681, 2020 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32416962
4.
Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.
Biochem Biophys Res Commun
; 522(1): 220-225, 2020 01 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31759626
5.
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Proc Natl Acad Sci U S A
; 114(52): E11293-E11302, 2017 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29229845
6.
Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.
Biometals
; 31(2): 267-276, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29516299
7.
Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.
Biochim Biophys Acta
; 1862(9): 1650-62, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27267344
8.
Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.
Biochim Biophys Acta
; 1862(6): 1084-92, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26957286
9.
Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.
Biochem Biophys Res Commun
; 468(1-2): 161-6, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26522227
10.
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
Neurobiol Dis
; 69: 263-75, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24844147
11.
Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain.
J Parkinsons Dis
; 2024 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38820022
12.
Human dementia with Lewy bodies brain shows widespread urea elevations.
Parkinsonism Relat Disord
; 124: 107017, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38788611
13.
Widespread selenium deficiency in the brain of cases with Huntington's disease presents a new potential therapeutic target.
EBioMedicine
; 97: 104824, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37806287
14.
Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias.
Front Mol Neurosci
; 16: 1215637, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37520429
15.
Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia.
Front Aging Neurosci
; 13: 641222, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33746735
16.
Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia.
Metabolites
; 11(9)2021 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34564384
17.
Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia.
Front Mol Neurosci
; 14: 711396, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34751215
18.
Generation of a mouse SWATH-MS spectral library to quantify 10148 proteins involved in cell reprogramming.
Sci Data
; 8(1): 118, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33903600
19.
A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.
J Huntingtons Dis
; 10(4): 423-434, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34420978
20.
Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease.
Neurobiol Dis
; 34(3): 450-6, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19281846