Detalles de la búsqueda
1.
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 91: 129362, 2023 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37295614
2.
INTEGRATE-Pain: a transatlantic consortium to advance development of effective pain management.
Pain Med
; 24(6): 730-733, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36951530
3.
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.
Bioorg Med Chem Lett
; 25(20): 4412-8, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26386604
4.
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.
Bioorg Med Chem Lett
; 25(14): 2793-9, 2015 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26022839
5.
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
Bioorg Med Chem Lett
; 23(1): 330-5, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23177783
6.
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
Bioorg Med Chem Lett
; 23(13): 3914-9, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23683593
7.
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders.
J Med Chem
; 66(18): 13135-13147, 2023 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37724542
8.
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.
Bioorg Med Chem Lett
; 21(22): 6856-60, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21962575
9.
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
J Med Chem
; 64(19): 14773-14792, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34613725
10.
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
Bioorg Med Chem Lett
; 20(3): 1128-33, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20022752
11.
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.
Nat Rev Neurol
; 16(7): 381-400, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32541893
12.
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Bioorg Med Chem Lett
; 19(20): 5872-6, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19740659
13.
Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
J Med Chem
; 50(6): 1365-79, 2007 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17315987
14.
Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.
J Med Chem
; 59(19): 8848-8858, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564419
15.
Central G-Protein Coupled Receptors (GPCR)s as molecular targets for the treatment of obesity: assets, liabilities and development status.
Curr Drug Targets CNS Neurol Disord
; 3(5): 357-77, 2004 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15544445
16.
The role of melanocortin peptides and receptors in regulation of energy balance.
Curr Pharm Des
; 9(8): 627-41, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12570796
17.
Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice.
Psychopharmacology (Berl)
; 170(2): 178-87, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12845406
18.
Behavioral and neuroendocrine effects of the selective CRF2 receptor agonists urocortin II and urocortin III.
Peptides
; 25(4): 659-66, 2004 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15165722
19.
Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.
J Med Chem
; 57(18): 7509-22, 2014 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25165888
20.
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
J Med Chem
; 56(23): 9586-600, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24182233