Detalles de la búsqueda
1.
Holistic drug design for multiparameter optimization in modern small molecule drug discovery.
Bioorg Med Chem Lett
; 41: 128003, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33798703
2.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24226772
3.
Total Synthesis as Training for Medicinal Chemistry.
ACS Med Chem Lett
; 15(2): 156-158, 2024 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38352841
4.
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.
Bioorg Med Chem Lett
; 23(15): 4459-64, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23769639
5.
Structure guided P1' modifications of HEA derived ß-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 22(11): 3607-11, 2012 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22572583
6.
Quinolinone-based agonists of S1P1: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Bioorg Med Chem Lett
; 22(1): 527-31, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22104144
7.
Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.
J Med Chem
; 63(17): 8956-8976, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32330036
8.
A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment.
J Org Chem
; 74(15): 5458-70, 2009 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-19534538
9.
The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization.
J Med Chem
; 60(9): 3552-3579, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28177632
10.
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.
J Med Chem
; 58(11): 4383-438, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25734370
11.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem
; 58(24): 9663-79, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26551034
12.
Total synthesis of the reputed structure of alcyonin and reassignment of its structure.
Org Lett
; 5(9): 1543-6, 2003 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12713319
13.
2,2'-Bi[benzo[b]thiophene]: an unexpected isolation of the benzo[b]thiophene dimer.
Acta Crystallogr C Struct Chem
; 70(Pt 6): 547-9, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24898955
14.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem
; 57(7): 3094-116, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24611879
15.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
J Med Chem
; 57(2): 309-24, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405172
16.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
17.
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.
ACS Med Chem Lett
; 3(1): 74-8, 2012 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900374
18.
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of ß-Secretase.
ACS Med Chem Lett
; 3(11): 886-91, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900403
19.
Design and preparation of a potent series of hydroxyethylamine containing ß-secretase inhibitors that demonstrate robust reduction of central ß-amyloid.
J Med Chem
; 55(21): 9009-24, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468639
20.
Design and synthesis of potent, orally efficacious hydroxyethylamine derived ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem
; 55(21): 9025-44, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468684