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1.
Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Basic Res Cardiol
; 116(1): 34, 2021 05 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34018053
2.
IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.
J Cell Mol Med
; 24(19): 11573-11582, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32858764
3.
Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design.
Mol Pharmacol
; 94(3): 1007-1030, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29976563
4.
Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.
Int J Mol Sci
; 19(10)2018 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30326568
5.
Discovery to Development: Insecticides for Malaria Vector Control.
Chimia (Aarau)
; 70(10): 684-693, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27779925
6.
Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors.
BMC Microbiol
; 14: 219, 2014 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-25183427
7.
Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
ACS Pharmacol Transl Sci
; 5(9): 735-751, 2022 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36110379
8.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol
; 28(6): 835-847.e5, 2021 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33662256
9.
Releasing the technical 'shackles' on GPCR drug discovery: opportunities enabled by detergent-free polymer lipid particle (PoLiPa) purification.
Drug Discov Today
; 2020 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32835806
10.
Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4.
Sci Rep
; 10(1): 12060, 2020 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32694738
11.
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Cell Stem Cell
; 24(4): 579-591.e12, 2019 04 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30853557
12.
Selection and early clinical evaluation of the brain-penetrant 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor UE2343 (Xanamem™).
Br J Pharmacol
; 174(5): 396-408, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28012176
13.
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Cell Stem Cell
; 26(3): 458, 2020 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32142664
14.
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
J Med Chem
; 57(22): 9447-62, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25365789
15.
Nonhuman targets in allergic lung conditions.
Future Med Chem
; 5(2): 147-61, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23360140
16.
[(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.
Dalton Trans
; (43): 4962-73, 2007 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-17992281
17.
Future inhaled drugs by virtual innovation: allergen delivery inhibitors.
Future Med Chem
; 3(13): 1567-70, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21942246
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