Detalles de la búsqueda
1.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32042197
2.
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition.
Bioorg Med Chem Lett
; 28(11): 2103-2108, 2018 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29709252
3.
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.
Bioorg Med Chem Lett
; 27(16): 3817-3824, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28684121
4.
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.
Bioorg Med Chem Lett
; 27(15): 3477-3485, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28629594
5.
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ACS Med Chem Lett
; 15(5): 714-721, 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38746903
6.
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
J Med Chem
; 67(6): 4676-4690, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38467640
7.
Discovery of BIO-8169âA Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
J Med Chem
; 67(10): 8383-8395, 2024 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38695469
8.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett
; 22(15): 4967-74, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22765895
9.
Cxcl10 Chemokine Induces Migration of ING4-Deficient Breast Cancer Cells via a Novel Cross Talk Mechanism between the Cxcr3 and Egfr Receptors.
Mol Cell Biol
; 42(2): e0038221, 2022 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34871062
10.
Synthesis of N-Substituted 3-Amino-2-pyridones.
Org Lett
; 24(33): 6133-6136, 2022 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35960821
11.
Management of hospitalized patients with mild to moderate diabetic ketoacidosis using a continuous insulin infusion protocol on a medical surgical ward and observation level of care: A retrospective cohort study.
Medicine (Baltimore)
; 101(31): e29665, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35945801
12.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
ACS Med Chem Lett
; 13(4): 665-673, 2022 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35450377
13.
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg Med Chem Lett
; 21(7): 2064-70, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21376583
14.
Rheumatologic Medication Use During Pregnancy.
Obstet Gynecol
; 135(5): 1161-1176, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32282595
15.
Correction to "Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement".
ACS Med Chem Lett
; 8(3): 378, 2017 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28337335
16.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
J Med Chem
; 60(14): 5990-6017, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324649
17.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
J Med Chem
; 60(14): 5969-5989, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28287723
18.
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J Med Chem
; 59(6): 2328-42, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26812066
19.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.
ACS Med Chem Lett
; 7(12): 1062-1067, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994738
20.
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
J Med Chem
; 58(5): 2417-30, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25699405