Detalles de la búsqueda
1.
Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations.
Arch Biochem Biophys
; 729: 109392, 2022 10 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36096178
2.
Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants.
Molecules
; 27(24)2022 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36557898
3.
Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses.
Hum Mol Genet
; 28(1): 1-15, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30215702
4.
Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.
Proc Natl Acad Sci U S A
; 114(31): E6332-E6341, 2017 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28720707
5.
Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.
Hum Mol Genet
; 26(18): 3531-3544, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28911204
6.
Warfarin increases thermal resistance of albumin through stabilization of the protein lobe that includes its binding site.
Arch Biochem Biophys
; 676: 108123, 2019 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31580875
7.
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J Biol Chem
; 292(3): 786-801, 2017 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27899452
8.
Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Hum Mol Genet
; 25(11): 2234-2244, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27005423
9.
Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.
Chembiochem
; 19(10): 1088-1095, 2018 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29505688
10.
Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.
Handb Exp Pharmacol
; 245: 155-190, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-28993836
11.
Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.
Handb Exp Pharmacol
; 245: 345-383, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29119254
12.
Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism.
Biochim Biophys Acta
; 1864(9): 1195-1205, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27179589
13.
Galactokinase promiscuity: a question of flexibility?
Biochem Soc Trans
; 44(1): 116-22, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26862196
14.
FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.
Biochim Biophys Acta
; 1842(11): 2163-73, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25179580
15.
The lower limits for protein stability and foldability in primary hyperoxaluria type I.
Biochim Biophys Acta
; 1844(12): 2355-65, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25461797
16.
The role of surface electrostatics on the stability, function and regulation of human cystathionine ß-synthase, a complex multidomain and oligomeric protein.
Biochim Biophys Acta
; 1844(9): 1453-62, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24780582
17.
The consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine-glyoxylate aminotransferase.
Biochem J
; 462(3): 453-63, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24957194
18.
The interplay between protein stability and dynamics in conformational diseases: the case of hPGK1 deficiency.
Biochim Biophys Acta
; 1834(12): 2502-11, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23911916
19.
The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.
Arch Biochem Biophys
; 562: 103-14, 2014 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25150110
20.
Insights into human phosphoglycerate kinase 1 deficiency as a conformational disease from biochemical, biophysical, and in vitro expression analyses.
J Inherit Metab Dis
; 37(6): 909-16, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24838780