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1.
Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.
Drug Metab Dispos
; 43(2): 190-8, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25384899
2.
Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.
Drug Metab Dispos
; 42(11): 1926-39, 2014 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25142735
3.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24418771
4.
The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies.
Toxicol Pathol
; 42(4): 696-708, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24771080
5.
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.
J Biol Chem
; 287(17): 13598-610, 2012 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22298776
6.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24239482
7.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23562063
8.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23831135
9.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.
Biochem J
; 441(3): 881-7, 2012 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22044397
10.
Glycomimetic ligands for the human asialoglycoprotein receptor.
J Am Chem Soc
; 134(4): 1978-81, 2012 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22280495
11.
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett
; 22(1): 415-20, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22119466
12.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23089526
13.
Exploring aromatic chemical space with NEAT: novel and electronically equivalent aromatic template.
J Chem Inf Model
; 52(5): 1114-23, 2012 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22486394
14.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36322383
15.
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Bioorg Med Chem Lett
; 21(9): 2725-31, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21183342
16.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34635855
17.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Mol Metab
; 48: 101196, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33667726
18.
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.
Bioorg Med Chem Lett
; 20(21): 6262-7, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20829042
19.
Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients.
J Am Soc Mass Spectrom
; 31(3): 498-507, 2020 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32013416
20.
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.
Cell Mol Gastroenterol Hepatol
; 10(4): 829-851, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32526482