Detalles de la búsqueda
1.
Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand.
J Labelled Comp Radiopharm
; 67(4): 120-130, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38332677
2.
Structural basis for positive allosteric modulation of AMPA and kainate receptors.
J Physiol
; 600(2): 181-200, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33938001
3.
Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.
Int J Mol Sci
; 23(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955932
4.
The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology.
Pharmacology
; 104(5-6): 332-341, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31484177
5.
Structural rearrangement of the intracellular domains during AMPA receptor activation.
Proc Natl Acad Sci U S A
; 113(27): E3950-9, 2016 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27313205
6.
In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury.
Eur J Neurosci
; 45(2): 238-248, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27859797
7.
Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.
Neurochem Res
; 42(12): 3401-3413, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28828633
8.
Investigation of antidepressant-like and anxiolytic-like actions and cognitive and motor side effects of four N-methyl-D-aspartate receptor antagonists in mice.
Behav Pharmacol
; 28(1): 37-47, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27740963
9.
Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.
Biophys J
; 110(11): 2397-2406, 2016 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27276258
10.
Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
; 202(1): 7-15, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26520141
11.
Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs.
Mol Pharm
; 13(7): 2484-91, 2016 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27266990
12.
Positive allosteric modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action.
Behav Pharmacol
; 27(6): 549-55, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27341500
13.
Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands.
Bioorg Med Chem Lett
; 26(22): 5568-5572, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27765511
14.
Blood-brain barrier permeability and brain uptake mechanism of kainic acid and dihydrokainic acid.
Neurochem Res
; 40(3): 542-9, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25488153
15.
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.
J Biol Chem
; 288(46): 33124-35, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24072709
16.
Analogues of 3-hydroxyisoxazole-containing glutamate receptor ligands based on the 3-hydroxypyrazole-moiety: design, synthesis and pharmacological characterization.
Neurochem Res
; 39(10): 1895-905, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24848194
17.
Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites.
Bioorg Med Chem
; 22(19): 5368-77, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25172149
18.
The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
FEBS Lett
; 598(7): 743-757, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38369668
19.
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
FEBS J
; 291(7): 1506-1529, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38145505
20.
Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
Eur J Med Chem
; 264: 116036, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38101041