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1.
Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.
Arch Toxicol
; 91(7): 2643-2653, 2017 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27896398
2.
Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.
Drug Metab Dispos
; 44(8): 1201-12, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27226351
3.
The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse.
Xenobiotica
; 44(2): 164-73, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24320884
4.
Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice.
Xenobiotica
; 44(2): 186-95, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417752
5.
Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.
Xenobiotica
; 42(2): 179-94, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21955289
6.
The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac.
Xenobiotica
; 42(2): 195-205, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21955249
7.
Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.
Xenobiotica
; 42(11): 1128-37, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22642803
8.
Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism.
Xenobiotica
; 41(8): 720-34, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21671748
9.
Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity.
Clin Cancer Res
; 22(20): 5130-5140, 2016 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27435396
10.
A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.
Biochem Pharmacol
; 92(4): 701-11, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25450676
11.
Drug-drug interactions and metabolism in cytochrome P450 2C knockout mice: application to troleandomycin and midazolam.
Biochem Pharmacol
; 86(4): 529-38, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23732297
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