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1.
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
Bioorg Med Chem
; 28(10): 115481, 2020 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32253095
2.
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
J Pharmacol Exp Ther
; 333(3): 797-807, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20237073
3.
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Bioorg Med Chem Lett
; 20(5): 1543-7, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20137931
4.
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Bioorg Med Chem Lett
; 19(16): 4882-4, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616942
5.
Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.
Bioorg Med Chem Lett
; 19(16): 4878-81, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616945
6.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30113844
7.
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.
ACS Chem Biol
; 12(12): 2970-2974, 2017 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29088528
8.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28498658
9.
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
J Med Chem
; 47(13): 3367-80, 2004 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15189033
10.
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
J Med Chem
; 55(2): 935-42, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22148323
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