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1.
Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.
Invest New Drugs
; 38(6): 1796-1806, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32451663
2.
Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.
Drug Metab Dispos
; 47(6): 648-656, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940629
3.
Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.
J Pharmacol Exp Ther
; 367(3): 414-424, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30228112
4.
Population pharmacokinetics of mobocertinib in healthy volunteers and patients with non-small cell lung cancer.
CPT Pharmacometrics Syst Pharmacol
; 11(6): 731-744, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35316867
5.
Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
AAPS J
; 20(2): 39, 2018 03 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29516207
6.
Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
AAPS J
; 20(3): 55, 2018 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29589158
7.
Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: a Novel Method to Handle the Interval Censoring Caused by Measurement of Smaller Tumors.
AAPS J
; 18(2): 404-15, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26757730
8.
Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes.
AAPS J
; 18(5): 1262-1272, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27329303
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