Detalles de la búsqueda
1.
Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 29(4): 659-663, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30638874
2.
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 28(5): 958-962, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439904
3.
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.
Mol Pharmacol
; 92(3): 310-317, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28645932
4.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28954811
5.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28818462
6.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
7.
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
Bioorg Med Chem Lett
; 23(2): 407-11, 2013 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23253443
8.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
9.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257579
10.
Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study.
EJNMMI Res
; 11(1): 66, 2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34287731
11.
Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.
J Psychopharmacol
; 33(1): 25-36, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30484737
12.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576602
13.
Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance.
Neuropharmacology
; 55(1): 63-70, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18538356
14.
Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats.
J Psychopharmacol
; 32(2): 146-155, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29378483
15.
Targeted disruption of the mouse Mel(1b) melatonin receptor.
Mol Cell Biol
; 23(3): 1054-60, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12529409
16.
Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment.
Pharmacol Biochem Behav
; 161: 53-61, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28911960
17.
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Eur J Pharmacol
; 799: 16-25, 2017 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28132910
18.
[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.
Neuropharmacology
; 118: 167-174, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28315351
19.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234467
20.
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.
Eur J Pharmacol
; 807: 1-11, 2017 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28438647