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1.
C2'-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level.
J Org Chem
; 83(4): 2473-2478, 2018 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29364674
2.
A minute amount of s-puckered sugars is sufficient for (6-4) photoproduct formation at the dinucleotide level.
J Org Chem
; 80(1): 615-9, 2015 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25496131
3.
Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
J Org Chem
; 75(18): 6122-40, 2010 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-20738147
4.
Synthesis and structure of azole-fused indeno[2,1-c]quinolines and their anti-mycobacterial properties.
Org Biomol Chem
; 8(24): 5661-73, 2010 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20927480
5.
Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
J Org Chem
; 74(9): 3248-65, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19348480
6.
Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
J Org Chem
; 74(1): 118-34, 2009 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-19055352
7.
Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations.
Org Biomol Chem
; 6(24): 4627-33, 2008 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-19039373
8.
Carbocyclic C-C Bond Formation: Intramolecular Radical Ring Closure to Yield Diastereomerically Pure (7'S-Me- or 7'R-Me-) Carba-LNA Nucleotide Analogs.
Curr Protoc Nucleic Acid Chem
; 69: 4.74.1-4.74.42, 2017 06 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-28628208
9.
How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
Mol Biosyst
; 13(5): 921-938, 2017 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28352859
10.
Molecular structure of the core-modified siRNA duplexes containing diastereomeric pair of [C6'(R)-OH]- versus [C6'(S)-OH]-carba-LNAs suggests a model for RNAi action.
Nucleosides Nucleotides Nucleic Acids
; 30(11): 815-25, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22060548
11.
Chemical and structural implications of 1',2'- versus 2',4'- conformational constraints in the sugar moiety of modified thymine nucleosides.
J Org Chem
; 72(13): 4716-26, 2007 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17523663
12.
Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
J Am Chem Soc
; 129(26): 8362-79, 2007 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17552524
13.
Synthesis and structure of novel conformationally constrained 1',2'-azetidine-fused bicyclic pyrimidine nucleosides: their incorporation into oligo-DNAs and thermal stability of the heteroduplexes.
J Org Chem
; 71(1): 299-314, 2006 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16388649
14.
Conformationally constrained 2'-N,4'-C-ethylene-bridged thymidine (aza-ENA-T): synthesis, structure, physical, and biochemical studies of aza-ENA-T-modified oligonucleotides.
J Am Chem Soc
; 128(47): 15173-87, 2006 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17117869
15.
The chemical nature of the 2'-substituent in the pentose-sugar dictates the pseudoaromatic character of the nucleobase (pKa) in DNA/RNA.
Org Biomol Chem
; 4(9): 1675-86, 2006 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16633560
16.
Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.
J Am Chem Soc
; 126(37): 11484-99, 2004 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15366894
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